Category:BGT 2 Methoxyestradiol Nanocrystal Colloidal Dispersion(B62776)
From BiomedGT
BGT_2-Methoxyestradiol Nanocrystal Colloidal Dispersion(B62776)
Lexical
Concept Code: B62776
(O)
Preferred Name: 2-Methoxyestradiol Nanocrystal Colloidal Dispersion
Coding Scheme: BGT (09.06a )
Synonym: Panzem NCD (BR) (Source: NCI) / 2-Methoxyestradiol Nanocrystal Colloidal Dispersion (PT) (Source: NCI)
Definition: An orally bioavailable liquid formulation containing the small molecule 2-methoxyestradiol with potential antineoplastic activity. 2-Methoxyestradiol, a naturally occurring estradiol metabolite, exerts its antitumor effect by inhibiting endothelial cells as well as tumor cells through multiple mechanisms. This agent binds to tubulin and disrupts microtubule formation, thereby preventing mitosis and subsequent cellular proliferation. In addition, 2-methoxyestradiol induces caspase activation resulting in cell cycle arrest in the G2 phase and eventually apoptosis. This agent also down-regulates hypoxia inducible factor-one alpha (HIF-1a). The nanocrystal colloidal dispersion increases the absorption of 2-methoxyestradiol, thereby improving its bioavailability resulting in enhanced drug plasma levels. (Source: NCI)
URI: http://ncicb.nci.nih.gov/xml/owl/EVS/BiomedGT.owl#B62776
Properties
Semantic_Type: Steroid
Semantic_Type: Pharmacologic Substance
Has_Target: Tubulin
PDQ_Open_Trial_Search_ID: 488412
PDQ_Closed_Trial_Search_ID: 488412
Associations
Parent: Steroid_Compound (primitive)
Parent: Selective_Estrogen_Receptor_Modulator (primitive)
Every instance of 2_Methoxyestradiol_Nanocrystal_Colloidal_Dispersion Chemical_Or_Drug_Has_Physiologic_Effect at least one instance of Inhibition_of_Cell_Proliferation.
Every instance of 2_Methoxyestradiol_Nanocrystal_Colloidal_Dispersion Chemical_Or_Drug_Has_Physiologic_Effect at least one instance of G2_Phase_Arrest.
Every instance of 2_Methoxyestradiol_Nanocrystal_Colloidal_Dispersion Chemical_Or_Drug_Has_Physiologic_Effect at least one instance of Induction_of_Apoptosis.
Every instance of 2_Methoxyestradiol_Nanocrystal_Colloidal_Dispersion Chemical_Or_Drug_Has_Physiologic_Effect at least one instance of Mitosis_Inhibition.
2_Methoxyestradiol_Nanocrystal_Colloidal_Dispersion Has_Target Tubulin
Form:LexWiki_BGT_Form
| BGT Chemical Or Drug Has Physiologic Effect(R125) | BGT Inhibition of Cell Proliferation(B20924) +, BGT G2 Phase Arrest(B40948) +, BGT Induction of Apoptosis(B20323) +, and BGT Mitosis Inhibition(B40957) + |
| BGT Concept Type(P365) | O + |
| BGT Has Target(A7) | Tubulin +, and BGT Tubulin(B17392) + |
| BGT PDQ Closed Trial Search ID(P330) | 488412 +info.pngPDQ Closed Trial Search |
| BGT PDQ Open Trial Search ID(P329) | 488412 +info.pngPDQ Open Trial Search |
| BGT Semantic Type(P106) | Steroid +info.pngSemantic Type lookup , and Pharmacologic Substance +info.pngSemantic Type lookup |
| BGT Synonym(P104) | Panzem NCD +, and 2-Methoxyestradiol Nanocrystal Colloidal Dispersion + |
| DCTerms hasVersion(hasVersion) | BGT/Versions/09.06a + |
| Has default form | LexWiki BGT Form + |
| LexWiki Concept Code | B62776 + |
| LexWiki Definition | An orally bioavailable liquid formulation … An orally bioavailable liquid formulation containing the small molecule 2-methoxyestradiol with potential antineoplastic activity. 2-Methoxyestradiol, a naturally occurring estradiol metabolite, exerts its antitumor effect by inhibiting endothelial cells as well as tumor cells through multiple mechanisms. This agent binds to tubulin and disrupts microtubule formation, thereby preventing mitosis and subsequent cellular proliferation. In addition, 2-methoxyestradiol induces caspase activation resulting in cell cycle arrest in the G2 phase and eventually apoptosis. This agent also down-regulates hypoxia inducible factor-one alpha (HIF-1a). The nanocrystal colloidal dispersion increases the absorption of 2-methoxyestradiol, thereby improving its bioavailability resulting in enhanced drug plasma levels. (Source: NCI) enhanced drug plasma levels. (Source: NCI) |
| LexWiki Preferred Name | 2-Methoxyestradiol Nanocrystal Colloidal Dispersion + |
| LexWiki URI | http://ncicb.nci.nih.gov/xml/owl/EVS/BiomedGT.owl#B62776 + |
| SKOS inScheme(inScheme) | BGT + |
This category currently contains no articles or media.
