Category:BGT CHP HER 2 Peptide Vaccine(B62770)
From BiomedGT
BGT_CHP-HER-2 Peptide Vaccine(B62770)
Lexical
Concept Code: B62770
(O)
Preferred Name: CHP-HER-2 Peptide Vaccine
Coding Scheme: BGT (09.06a )
Synonym: Cholesterol-Bearing Hydrophobized Pullulan HER2 Protein 146 (SY) (Source: NCI) / CHP-HER-2 Peptide Vaccine (PT) (Source: NCI)
Definition: A peptide vaccine containing nanoparticles of cholesterol-bearing hydrophobized pullulan (CHP) complexed with the tumor-associated antigen HER-2/neu (ErbB-2) with potential antineoplastic activity. Her-2/neu, a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various tumors, including breast, ovarian and gastric cancers. Vaccination with CHP-HER-2 peptide vaccine may stimulate the host immune system to mount a humoral as well as a cytotoxic T-cell response against tumor cells expressing the HER-2/neu antigen. This results in an inhibition of tumor cell proliferation and tumor cell death. The self-aggregating CHP, composed of a pullulan backbone and cholesterol branches, forms stable colloidal nanoparticles in water. (Source: NCI)
URI: http://ncicb.nci.nih.gov/xml/owl/EVS/BiomedGT.owl#B62770
Properties
Semantic_Type: Immunologic Factor
Semantic_Type: Pharmacologic Substance
PDQ_Open_Trial_Search_ID: 489124
PDQ_Closed_Trial_Search_ID: 489124
Associations
Parent: Peptide_Vaccine (primitive)
Every instance of CHP_HER_2_Peptide_Vaccine Chemical_Or_Drug_Has_Physiologic_Effect at least one instance of Immunopotentiation.
Every instance of CHP_HER_2_Peptide_Vaccine Chemical_Or_Drug_Has_Physiologic_Effect at least one instance of T_Cell_Activation.
Every instance of CHP_HER_2_Peptide_Vaccine Chemical_Or_Drug_Has_Mechanism_Of_Action at least one instance of Antigen_Sensitization.
Every instance of CHP_HER_2_Peptide_Vaccine Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue at least one instance of Cytotoxic_T_Lymphocyte.
Form:LexWiki_BGT_Form
| BGT Chemical Or Drug Affects Cell Type Or Tissue(R72) | BGT Cytotoxic T Lymphocyte(B12716) + |
| BGT Chemical Or Drug Has Mechanism Of Action(R124) | BGT Antigen Sensitization(B45721) + |
| BGT Chemical Or Drug Has Physiologic Effect(R125) | BGT Immunopotentiation(B41085) +, and BGT T Cell Activation(B19226) + |
| BGT Concept Type(P365) | O + |
| BGT PDQ Closed Trial Search ID(P330) | 489124 +info.pngPDQ Closed Trial Search |
| BGT PDQ Open Trial Search ID(P329) | 489124 +info.pngPDQ Open Trial Search |
| BGT Semantic Type(P106) | Immunologic Factor +info.pngSemantic Type lookup , and Pharmacologic Substance +info.pngSemantic Type lookup |
| BGT Synonym(P104) | Cholesterol-Bearing Hydrophobized Pullulan HER2 Protein 146 +, and CHP-HER-2 Peptide Vaccine + |
| DCTerms hasVersion(hasVersion) | BGT/Versions/09.06a + |
| Has default form | LexWiki BGT Form + |
| LexWiki Concept Code | B62770 + |
| LexWiki Definition | A peptide vaccine containing nanoparticles … A peptide vaccine containing nanoparticles of cholesterol-bearing hydrophobized pullulan (CHP) complexed with the tumor-associated antigen HER-2/neu (ErbB-2) with potential antineoplastic activity. Her-2/neu, a member of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, is overexpressed in various tumors, including breast, ovarian and gastric cancers. Vaccination with CHP-HER-2 peptide vaccine may stimulate the host immune system to mount a humoral as well as a cytotoxic T-cell response against tumor cells expressing the HER-2/neu antigen. This results in an inhibition of tumor cell proliferation and tumor cell death. The self-aggregating CHP, composed of a pullulan backbone and cholesterol branches, forms stable colloidal nanoparticles in water. (Source: NCI) idal nanoparticles in water. (Source: NCI) |
| LexWiki Preferred Name | CHP-HER-2 Peptide Vaccine + |
| LexWiki URI | http://ncicb.nci.nih.gov/xml/owl/EVS/BiomedGT.owl#B62770 + |
| SKOS inScheme(inScheme) | BGT + |
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