Category:BGT Colloidal Gold Bound Tumor Necrosis Factor(B62711)

From BiomedGT

BGT_Colloidal Gold-Bound Tumor Necrosis Factor(B62711)

Lexical

Concept Code: B62711 (O)
Preferred Name: Colloidal Gold-Bound Tumor Necrosis Factor
Coding Scheme: BGT (09.06a )
Synonym: TNF-bound colloidal gold (SY) (Source: NCI) / Colloidal Gold-Bound Tumor Necrosis Factor (PT) (Source: NCI) / colloidal gold-bound TNF (SY) (Source: NCI) / colloidal gold-bound rhTNF (SY) (Source: NCI) / Colloidal Gold-Bound Recombinant Human Tumor Necrosis Factor (SY) (Source: NCI) / CYT-6091 (CN) (Source: NCI) / Aurimmune (BR) (Source: NCI)
Definition: A nanoparticle delivery system comprised of the recombinant human tumor necrosis factor (TNF) bound to pegylated colloidal gold nanoparticles with potential antineoplastic activity. Upon intravenous administration, colloidal gold-bound recombinant human TNF travels through the bloodstream, avoiding immune detection and uptake by the reticuloendothelial system, and accumulates in tumor tissues. The delivery of TNF to the tumor leads to a decrease in cellular proliferation and increase in apoptosis. Compared to the administration of native TNF, colloidal gold-bound TNF improves the safety and efficacy of TNF treatment by delivering TNF directly to its target site. (Source: NCI)
URI: http://ncicb.nci.nih.gov/xml/owl/EVS/BiomedGT.owl#B62711

Properties

Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Pharmacologic Substance
PDQ_Open_Trial_Search_ID: 492715
PDQ_Closed_Trial_Search_ID: 492715

Associations

Parent: Recombinant_Tumor_Necrosis_Factor_Family_Protein (primitive)

Every instance of Colloidal_Gold_Bound_Tumor_Necrosis_Factor Chemical_Or_Drug_Has_Physiologic_Effect at least one instance of Induction_of_Apoptosis.
Every instance of Colloidal_Gold_Bound_Tumor_Necrosis_Factor Chemical_Or_Drug_Has_Mechanism_Of_Action at least one instance of Cytokine_Receptor_Activation.

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