Category:CTCAE4 Blood and lymphatic system disorders
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| Adverse Event | Grade1 | Grade2 | Grade3 | Grade4 | Grade5 |
|---|---|---|---|---|---|
| Anemia | Hemoglobin (Hgb) <LLN - 10.0 g/dL; <LLN - 6.2 mmol/L; <LLN - 100 g/L | Hgb <10.0 - 8.0 g/dL; <6.2 - 4.9 mmol/L; <100 - 80g/L | Hgb <8.0 - 6.5 g/dL; <4.9 - 4.0 mmol/L; <80 - 65 g/L; transfusion indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Blood and lymphatic system disorders - Other, specify | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Bone marrow hypocellular | Mildly hypocellular or <=25% reduction from normal cellularity for age | Moderately hypocellular or >25 - <50% reduction from normal cellularity for age | Severely hypocellular or >50 - <=75% reduction cellularity from normal for age | Aplastic persistent for longer than 2 weeks | Death |
| Disseminated intravascular coagulation | - | Laboratory findings with no bleeding | Laboratory findings and bleeding | Life-threatening consequences; urgent intervention indicated | Death |
| Febrile neutropenia | - | - | Present | Life-threatening consequences; urgent intervention indicated | Death |
| Hemolysis | Laboratory evidence of hemolysis only (e.g., direct antiglobulin test; DAT; Coombs'; schistocytes; decreased haptoglobin) | Evidence of hemolysis and >=2 gm decrease in hemoglobin, no transfusion | Transfusion or medical intervention indicated (e.g., steroids) | Life-threatening consequences; urgent intervention indicated | Death |
| Hemolytic uremic syndrome | Evidence of RBC destruction (schistocytosis) without clinical consequences | - | Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) | Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) | Death |
| Leukocytosis | - | - | >100,000/mm3 | Clinical manifestations of leucostasis; urgent intervention indicated | Death |
| Lymph node pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Spleen disorder | Incidental findings (e.g., Howell-Jolly bodies); mild degree of thrombocytosis and leukocytosis | Prophylactic antibiotics indicated | - | Life-threatening consequences; urgent intervention indicated | Death |
| Thrombotic thrombocytopenic purpura | Evidence of RBC destruction (schistocytosis) without clinical consequences | - | Laboratory findings with clinical consequences (e.g., renal insufficiency, petechiae) | Life-threatening consequences, (e.g., CNS hemorrhage or thrombosis/embolism or renal failure) | Death |
Articles in category "CTCAE4 Blood and lymphatic system disorders"
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