Category:CTCAE4 Cardiac disorders
From BiomedGT
Submit Comments | FAQ | Help
| Adverse Event | Grade1 | Grade2 | Grade3 | Grade4 | Grade5 |
|---|---|---|---|---|---|
| Acute coronary syndrome | - | Symptomatic, progressive angina; cardiac enzymes normal; hemodynamically stable | Symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically stable | Symptomatic, unstable angina and/or acute myocardial infarction, cardiac enzymes abnormal, hemodynamically unstable | Death |
| Aortic valve disease | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death |
| Asystole | Periods of asystole; non-urgent medical management indicated | - | - | Life-threatening consequences; urgent intervention indicated | Death |
| Atrial fibrillation | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation | Life-threatening consequences; urgent intervention indicated | Death |
| Atrial flutter | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker), or ablation | Life-threatening consequences; urgent intervention indicated | Death |
| Atrioventricular block complete | - | Non-urgent intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) | Life-threatening consequences; urgent intervention indicated | Death |
| Atrioventricular block first degree | Asymptomatic, intervention not indicated | Non-urgent intervention indicated | - | - | - |
| Cardiac arrest | - | - | - | Life-threatening consequences; urgent intervention indicated | Death |
| Cardiac disorders - Other, specify | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Chest pain - cardiac | Mild pain | Moderate pain; limiting instrumental ADL | Pain at rest; limiting self care ADL | - | - |
| Conduction disorder | Mild symptoms; intervention not indicated | Moderate symptoms | Severe symptoms; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Constrictive pericarditis | - | - | Symptomatic heart failure or other cardiac symptoms, responsive to intervention | Refractory heart failure or other poorly controlled cardiac symptoms | Death |
| Heart failure | Asymptomatic with laboratory (e.g., BNP _B-Natriuretic Peptide _) or cardiac imaging abnormalities | Symptoms with mild to moderate activity or exertion | Severe with symptoms at rest or with minimal activity or exertion; intervention indicated | Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) | Death |
| Left ventricular systolic dysfunction | - | - | Symptomatic due to drop in ejection fraction responsive to intervention | Refractory or poorly controlled heart failure due to drop in ejection fraction; intervention such as ventricular assist device, intravenous vasopressor support, or heart transplant indicated | Death |
| Mitral valve disease | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death |
| Mobitz (type) II atrioventricular block | Asymptomatic, intervention not indicated | Symptomatic; medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) | Life-threatening consequences; urgent intervention indicated | Death |
| Mobitz type I | Asymptomatic, intervention not indicated | Symptomatic; medical intervention indicated | Symptomatic and incompletely controlled medically, or controlled with device (e.g., pacemaker) | Life-threatening consequences; urgent intervention indicated | Death |
| Myocardial infarction | - | Asymptomatic and cardiac enzymes minimally abnormal and no evidence of ischemic ECG changes | Severe symptoms; cardiac enzymes abnormal; hemodynamically stable; ECG changes consistent with infarction | Life-threatening consequences; hemodynamically unstable | Death |
| Myocarditis | Asymptomatic with laboratory (e.g., BNP _B-Natriuretic Peptide _) or cardiac imaging abnormalities | Symptoms with mild to moderate activity or exertion | Severe with symptoms at rest or with minimal activity or exertion; intervention indicated | Life-threatening consequences; urgent intervention indicated (e.g., continuous IV therapy or mechanical hemodynamic support) | Death |
| Palpitations | Mild symptoms; intervention not indicated | Intervention indicated | - | - | - |
| Paroxysmal atrial tachycardia | Asymptomatic, intervention not indicated | Symptomatic; medical management indicated | IV medication indicated | Life-threatening consequences; incompletely controlled medically; cardioversion indicated | Death |
| Pericardial effusion | - | Asymptomatic effusion size small to moderate | Effusion with physiologic consequences | Life-threatening consequences; urgent intervention indicated | Death |
| Pericardial tamponade | - | - | - | Life-threatening consequences; urgent intervention indicated | Death |
| Pericarditis | Asymptomatic, ECG or physical findings (e.g., rub) consistent with pericarditis | Symptomatic pericarditis (e.g., chest pain) | Pericarditis with physiologic consequences (e.g., pericardial constriction) | Life-threatening consequences; urgent intervention indicated | Death |
| Pulmonary valve disease | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis by imaging | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis by imaging; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death |
| Restrictive cardiomyopathy | - | - | Symptomatic heart failure or other cardiac symptoms, responsive to intervention | Refractory heart failure or other poorly controlled cardiac symptoms | Death |
| Right ventricular dysfunction | Asymptomatic with laboratory (e.g., BNP _B-Natriuretic Peptide _) or cardiac imaging abnormalities | Symptoms with mild to moderate activity or exertion | Severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated | Life-threatening consequences; urgent intervention indicated (e.g., ventricular assist device); heart transplant indicated | Death |
| Sick sinus syndrome | Asymptomatic, intervention not indicated | Non-urgent intervention indicated | Severe, medically significant; medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Sinus bradycardia | Asymptomatic, intervention not indicated | Symptomatic, medical intervention indicated | Severe, medically significant, medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Sinus tachycardia | Asymptomatic, intervention not indicated | Symptomatic; non-urgent medical intervention indicated | Urgent medical intervention indicated | - | - |
| Supraventricular tachycardia | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Tricuspid valve disease | Asymptomatic valvular thickening with or without mild valvular regurgitation or stenosis | Asymptomatic; moderate regurgitation or stenosis by imaging | Symptomatic; severe regurgitation or stenosis; symptoms controlled with medical intervention | Life-threatening consequences; urgent intervention indicated (e.g., valve replacement, valvuloplasty) | Death |
| Ventricular arrhythmia | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Medical intervention indicated | Life-threatening consequences; hemodynamic compromise; urgent intervention indicated | Death |
| Ventricular fibrillation | - | - | - | Life-threatening consequences; hemodynamic compromise; urgent intervention indicated | Death |
| Ventricular tachycardia | - | Non-urgent medical intervention indicated | Medical intervention indicated | Life-threatening consequences; hemodynamic compromise; urgent intervention indicated | Death |
| Wolff-Parkinson-White syndrome | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Symptomatic and incompletely controlled medically or controlled with procedure | Life-threatening consequences; urgent intervention indicated | Death |
Articles in category "CTCAE4 Cardiac disorders"
There are 36 articles in this category.
