Category:CTCAE4 Eye disorders

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Adverse Event Grade1 Grade2 Grade3 Grade4 Grade5
Blurred vision Intervention not indicated Symptomatic; limiting instrumental ADL Limiting self care ADL - -
Cataract Asymptomatic; clinical or diagnostic observations only; intervention not indicated Symptomatic; moderate decrease in visual acuity (20/40 or better) Symptomatic with marked decrease in visual acuity (worse than 20/40 but better than 20/200); operative intervention indicated (e.g., cataract surgery) Blindness (20/200 or worse) in the affected eye -
Conjunctivitis Asymptomatic or mild symptoms; intervention not indicated Symptomatic; topical intervention indicated (e.g., antibiotics); limiting instrumental ADL Limiting self care ADL - -
Corneal ulcer - Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL Limiting self care ADL; declining vision (worse than 20/40 but better than 20/200) Perforation or blindness (20/200 or worse) in the affected eye -
Dry eye Asymptomatic; clinical or diagnostic observations only; mild symptoms relieved by lubricants Symptomatic; multiple agents indicated; limiting instrumental ADL Decrease in visual acuity (<20/40); limiting self care ADL - -
Extraocular muscle paresis Asymptomatic; clinical or diagnostic observations only Symptomatic; limiting instrumental ADL Limiting self care ADL; disabling - -
Eye disorders - Other, specify Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Severe or medically significant but not immediately sight-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL Sight-threatening consequences; urgent intervention indicated; blindness (20/200 or worse) in the affected eye -
Eye pain Mild pain Moderate pain; limiting instrumental ADL Severe pain; limiting self care ADL - -
Eyelid function disorder Asymptomatic; clinical or diagnostic observations only; intervention not indicated Symptomatic; nonoperative intervention indicated; limiting instrumental ADL Limiting self care ADL; operative intervention indicated - -
Flashing lights Symptomatic but not limiting ADL Limiting instrumental ADL Limiting self care ADL - -
Floaters Symptomatic but not limiting ADL Limiting instrumental ADL Limiting self care ADL - -
Glaucoma Elevated intraocular pressure (EIOP) with single topical agent for intervention; no visual field deficit EIOP causing early visual field deficits; multiple topical or oral agents indicated; limiting instrumental ADL EIOP causing marked visual field deficits (e.g., involving both superior and inferior visual fields); operative intervention indicated; limiting self care ADL Blindness (20/200 or worse) in the affected eye -
Keratitis - Symptomatic; medical intervention indicated (e.g., topical agents); limiting instrumental ADL Decline in vision (worse than 20/40 but better than 20/200); limiting self care ADL Perforation or blindness (20/200 or worse) in the affected eye -
Night blindness Symptomatic but not limiting ADL Limiting instrumental ADL Limiting self care ADL Blindness (20/200 or worse) in the affected eye -
Optic nerve disorder Asymptomatic; clinical or diagnostic observations only Limiting vision of the affected eye (20/40 or better); Limiting vision in the affected eye (worse than 20/40 but better than 20/200) Blindness (20/200 or worse) in the affected eye -
Papilledema Asymptomatic; no visual field defects Symptomatic decline in vision; visual field defect present sparing the central 20 degrees Marked visual field defect (worse than 20/40 but better than 20/200) Blindness (20/200 or worse) in the affected eye -
Photophobia Symptomatic but not limiting ADL Limiting instrumental ADL Limiting self care ADL - -
Retinal detachment Asymptomatic Exudative and visual acuity 20/40 or better Rhegmatogenous or exudative detachment; operative intervention indicated; decline in vision (worse than 20/40 but better than 20/200) Blindness (20/200 or worse) in the affected eye -
Retinal tear - Laser therapy or pneumopexy indicated Vitroretinal surgical repair indicated Blindness (20/200 or worse) in the affected eye -
Retinal vascular disorder - Topical medication indicated Intravitreal medication; operative intervention indicated - -
Retinopathy Asymptomatic; clinical or diagnostic observations only Symptomatic with moderate decrease in visual acuity (20/40 or better); limiting instrumental ADL Symptomatic with marked decrease in visual acuity (worse than 20/40); disabling; limiting self care ADL Blindness (20/200 or worse) in the affected eye -
Scleral disorder Asymptomatic; clinical or diagnostic observations only Symptomatic, limiting instrumental ADL; moderate decrease in visual acuity (20/40 or better) Symptomatic, limiting self care ADL; marked decrease in visual acuity (worse than 20/40) Blindness (20/200 or worse) in the affected eye -
Uveitis Asymptomatic; clinical or diagnostic observations only Anterior uveitis; medical intervention indicated Posterior or pan-uveitis Blindness (20/200 or worse) in the affected eye -
Vitreous hemorrhage Asymptomatic or mild symptoms; clinical or diagnostic observations only Symptomatic; limiting instrumental ADL Limiting self care ADL; vitrectomy indicated Blindness (20/200 or worse) in the affected eye -
Watering eyes Intervention not indicated Intervention indicated Operative intervention indicated - -
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