Category:CTCAE4 Gastrointestinal disorders
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| Adverse Event | Grade1 | Grade2 | Grade3 | Grade4 | Grade5 |
|---|---|---|---|---|---|
| Abdominal distension | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; limiting instrumental ADL | Severe discomfort; limiting self care ADL | - | - |
| Abdominal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Anal fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Anal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Anal mucositis | Asymptomatic or mild symptoms; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Anal necrosis | - | - | TPN or hospitalization indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Anal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Anal stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Symptomatic and severely altered GI function; non-emergent operative intervention indicated; TPN or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Anal ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Ascites | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; invasive intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Bloating | No change in bowel function or oral intake | Symptomatic, decreased oral intake; change in bowel function | - | - | - |
| Cecal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Cheilitis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL; intervention indicated | - | - |
| Colitis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Abdominal pain; mucus or blood in stool | Severe abdominal pain; change in bowel habits; medical intervention indicated; peritoneal signs | Life-threatening consequences; urgent intervention indicated | Death |
| Colonic fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; bowel rest, TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Colonic hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Colonic obstruction | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Hospitalization indicated; elective operative intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Colonic perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Colonic stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Colonic ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Constipation | Occasional or intermittent symptoms; occasional use of stool softeners, laxatives, dietary modification, or enema | Persistent symptoms with regular use of laxatives or enemas; limiting instrumental ADL | Obstipation with manual evacuation indicated; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Dental caries | One or more dental caries, not involving the root | Dental caries involving the root | Dental caries resulting in pulpitis or periapical abscess or resulting in tooth loss | - | - |
| Diarrhea | Increase of <4 stools per day over baseline; mild increase in ostomy output compared to baseline | Increase of 4 - 6 stools per day over baseline; moderate increase in ostomy output compared to baseline | Increase of >=7 stools per day over baseline; incontinence; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Dry mouth | Symptomatic (e.g., dry or thick saliva) without significant dietary alteration; unstimulated saliva flow >0.2 ml/min | Moderate symptoms; oral intake alterations (e.g., copious water, other lubricants, diet limited to purees and/or soft, moist foods); unstimulated saliva 0.1 to 0.2 ml/min | Inability to adequately aliment orally; tube feeding or TPN indicated; unstimulated saliva <0.1 ml/min | - | - |
| Duodenal fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Duodenal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Duodenal obstruction | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Hospitalization or elective operative intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Duodenal perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Duodenal stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Duodenal ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; medical intervention indicated; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Dyspepsia | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Severe symptoms; surgical intervention indicated | - | - |
| Dysphagia | Symptomatic, able to eat regular diet | Symptomatic and altered eating/swallowing | Severely altered eating/swallowing; tube feeding or TPN or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Enterocolitis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Abdominal pain; mucus or blood in stool | Severe or persistent abdominal pain; fever; ileus; peritoneal signs | Life-threatening consequences; urgent intervention indicated | Death |
| Enterovesical fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; noninvasive intervention indicated | Severe, medically significant; medical intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Esophageal fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Esophageal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Esophageal necrosis | - | - | Inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Esophageal obstruction | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent intervention indicated | Death |
| Esophageal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Esophageal perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Esophageal stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Esophageal ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Esophageal varices hemorrhage | - | Self-limited; intervention not indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Esophagitis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered eating/swallowing; oral supplements indicated | Severely altered eating/swallowing; tube feeding, TPN or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Fecal incontinence | Occasional use of pads required | Daily use of pads required | Severe symptoms; elective operative intervention indicated | - | - |
| Flatulence | Mild symptoms; intervention not indicated | Moderate; persistent; psychosocial sequelae | - | - | - |
| Gastric fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; bowel rest; tube feeding, TPN or hospitalization indicated ; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Gastric hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Gastric necrosis | - | - | Inability to aliment adequately by GI tract; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Gastric perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Gastric stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Gastric ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; medical intervention indicated; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Gastritis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; medical intervention indicated | Severely altered eating or gastric function; TPN or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Gastroesophageal reflux disease | Mild symptoms; intervention not indicated | Moderate symptoms; medical intervention indicated | Severe symptoms; surgical intervention indicated | - | - |
| Gastrointestinal disorders - Other, specify | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Gastrointestinal fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding, TPN or hospitalization indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Gastrointestinal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Gastroparesis | Mild nausea, early satiety and bloating, able to maintain caloric intake on regular diet | Moderate symptoms; able to maintain nutrition with dietary and lifestyle modifications; may need pharmacologic intervention | Weight loss; refractory to medical intervention; unable to maintain nutrition orally | - | - |
| Gingival pain | Mild pain | Moderate pain interfering with oral intake | Severe pain; inability to aliment orally | - | - |
| Hemorrhoidal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Hemorrhoids | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; banding or medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | - | - |
| Ileal fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Ileal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Ileal obstruction | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Ileal perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Ileal stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Ileal ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Ileus | - | Symptomatic; altered GI function; bowel rest indicated | Severely altered GI function; TPN indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Intra-abdominal hemorrhage | - | Medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Jejunal fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Jejunal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Jejunal obstruction | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Jejunal perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Jejunal stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Jejunal ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Lip pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Lower gastrointestinal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Malabsorption | - | Altered diet; oral intervention indicated | Inability to aliment adequately; TPN indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Mucositis oral | Asymptomatic or mild symptoms; intervention not indicated | Moderate pain; not interfering with oral intake; modified diet indicated | Severe pain; interfering with oral intake | Life-threatening consequences; urgent intervention indicated | Death |
| Nausea | Loss of appetite without alteration in eating habits | Oral intake decreased without significant weight loss, dehydration or malnutrition | Inadequate oral caloric or fluid intake; tube feeding, TPN, or hospitalization indicated | - | - |
| Obstruction gastric | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Oral cavity fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Oral dysesthesia | Mild discomfort; not interfering with oral intake | Moderate pain; interfering with oral intake | Disabling pain; tube feeding or TPN indicated | - | - |
| Oral hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Oral pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Pancreatic duct stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Pancreatic fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Pancreatic hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Pancreatic necrosis | - | - | Tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Pancreatitis | - | Enzyme elevation or radiologic findings only | Severe pain; vomiting; medical intervention indicated (e.g., analgesia, nutritional support) | Life-threatening consequences; urgent intervention indicated | Death |
| Periodontal disease | Gingival recession or gingivitis; limited bleeding on probing; mild local bone loss | Moderate gingival recession or gingivitis; multiple sites of bleeding on probing; moderate bone loss | Spontaneous bleeding; severe bone loss with or without tooth loss; osteonecrosis of maxilla or mandible | - | - |
| Peritoneal necrosis | - | - | Tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Proctitis | Rectal discomfort, intervention not indicated | Symptoms (e.g., rectal discomfort, passing blood or mucus); medical intervention indicated; limiting instrumental ADL | Severe symptoms; fecal urgency or stool incontinence; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Rectal fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; TPN or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Rectal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Rectal mucositis | Asymptomatic or mild symptoms; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent operative intervention indicated | Death |
| Rectal necrosis | - | - | Tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Rectal obstruction | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Rectal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Rectal perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Rectal stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Severely altered GI function; tube feeding or hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Rectal ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function (e.g. altered dietary habits, vomiting, diarrhea) | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Retroperitoneal hemorrhage | - | Self-limited; intervention indicated | Transfusion, medical, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Salivary duct inflammation | Slightly thickened saliva; slightly altered taste (e.g., metallic) | Thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL | Acute salivary gland necrosis; severe secretion-induced symptoms (e.g., thick saliva/oral secretions or gagging); tube feeding or TPN indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent intervention indicated | Death |
| Salivary gland fistula | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; tube feeding indicated | Severely altered GI function; hospitalization indicated; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Small intestinal mucositis | Asymptomatic or mild symptoms; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe pain; interfering with oral intake; tube feeding, TPN or hospitalization indicated; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Small intestinal obstruction | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Hospitalization indicated; elective operative intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Small intestinal perforation | - | Symptomatic; medical intervention indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Small intestinal stenosis | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function | Symptomatic and severely altered GI function; tube feeding, TPN or hospitalization indicated; non-emergent operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Small intestine ulcer | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; altered GI function; limiting instrumental ADL | Severely altered GI function; TPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL; disabling | Life-threatening consequences; urgent operative intervention indicated | Death |
| Stomach pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Tooth development disorder | Asymptomatic; hypoplasia of tooth or enamel | Impairment correctable with oral surgery | Maldevelopment with impairment not surgically correctable; disabling | - | - |
| Tooth discoloration | Surface stains | - | - | - | - |
| Toothache | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Typhlitis | - | - | Symptomatic (e.g., abdominal pain, fever, change in bowel habits with ileus); peritoneal signs | Life-threatening consequences; urgent operative intervention indicated | Death |
| Upper gastrointestinal hemorrhage | Mild; intervention not indicated | Moderate symptoms; medical intervention or minor cauterization indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Vomiting | 1 - 2 episodes (separated by 5 minutes) in 24 hrs | 3 - 5 episodes (separated by 5 minutes) in 24 hrs | >=6 episodes (separated by 5 minutes) in 24 hrs; tube feeding, TPN or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death |
Articles in category "CTCAE4 Gastrointestinal disorders"
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