Category:CTCAE4 Immune system disorders

From BiomedGT

Adverse Event	Grade1	Grade2	Grade3	Grade4	Grade5
Allergic reaction	Transient flushing or rash, drug fever <38 degrees C (<100.4 degrees F); intervention not indicated	Intervention or infusion interruption indicated; responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics); prophylactic medications indicated for <=24 hrs	Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates)	Life-threatening consequences; urgent intervention indicated	Death
Anaphylaxis	-	-	Symptomatic bronchospasm, with or without urticaria; parenteral intervention indicated; allergy-related edema/angioedema; hypotension	Life-threatening consequences; urgent intervention indicated	Death
Autoimmune disorder	Asymptomatic; serologic or other evidence of autoimmune reaction, with normal organ function; intervention not indicated	Evidence of autoimmune reaction involving a non-essential organ or function (e.g., hypothyroidism)	Autoimmune reactions involving major organ (e.g., colitis, anemia, myocarditis, kidney)	Life-threatening consequences; urgent intervention indicated	Death
Cytokine release syndrome	Mild reaction; infusion interruption not indicated; intervention not indicated	Therapy or infusion interruption indicated but responds promptly to symptomatic treatment (e.g., antihistamines, NSAIDS, narcotics, IV fluids); prophylactic medications indicated for <=24 hrs	Prolonged (e.g., not rapidly responsive to symptomatic medication and/or brief interruption of infusion); recurrence of symptoms following initial improvement; hospitalization indicated for clinical sequelae (e.g., renal impairment, pulmonary infiltrates)	Life-threatening consequences; pressor or ventilatory support indicated	Death
Immune system disorders - Other, specify	Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated	Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL	Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL	Life-threatening consequences; urgent intervention indicated	Death
Serum sickness	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Moderate arthralgia; fever, rash, urticaria, antihistamines indicated	Severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated	Life-threatening consequences; pressor or ventilatory support indicated	Death