Category:CTCAE4 Metabolism and nutrition disorders
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| Adverse Event | Grade1 | Grade2 | Grade3 | Grade4 | Grade5 |
|---|---|---|---|---|---|
| Acidosis | pH <normal, but =>7.3 | - | pH <7.3 | Life-threatening consequences | Death |
| Alcohol intolerance | - | Present | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Alkalosis | pH >normal, but <=7.5 | - | pH >7.5 | Life-threatening consequences | Death |
| Anorexia | Loss of appetite without alteration in eating habits | Oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated | Associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Dehydration | Increased oral fluids indicated; dry mucous membranes; diminished skin turgor | IV fluids indicated <24 hrs | IV fluids or hospitalization indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Glucose intolerance | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; dietary modification or oral agent indicated | Severe symptoms; insulin indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Hypercalcemia | >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L | >11.5 - 12.5 mg/dL ; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic | >12.5 - 13.5 mg/dL ;>3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated | >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences | Death |
| Hyperglycemia | Fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L | Fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L | >250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated | >500 mg/dL; >27.8 mmol/L; life-threatening consequences | Death |
| Hyperkalemia | >ULN - 5.5 mmol/L | >5.5 - 6.0 mmol/L | >6.0 - 7.0 mmol/L; hospitalization indicated | >7.0 mmol/L; life-threatening consequences | Death |
| Hypermagnesemia | >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L | - | >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L | >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences | Death |
| Hypernatremia | >ULN - 150 mmol/L | >150 - 155 mmol/L | >155 - 160 mmol/L; hospitalization indicated | >160 mmol/L; life-threatening consequences | Death |
| Hypertriglyceridemia | 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42mmol/L | >300 mg/dL - 500 mg/dL; >3.42 mmol/L- 5.7 mmol/L | >500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L | >1000 mg/dL; >11.4 mmol/L; life-threatening consequences | Death |
| Hyperuricemia | >ULN - 10 mg/dL; <=0.59 mmol/L without physiologic consequences | - | >ULN - 10 mg/dL; <=0.59 mmol/L with physiologic consequences | >10 mg/dL; >0.59 mmol/L; life-threatening consequences | Death |
| Hypoalbuminemia | <LLN - 3 g/dL ;<LLN - 30 g/L | <3 - 2 g/dL; <30 - 20 g/L | <2 g/dL; <20 g/L | Life-threatening consequences; urgent intervention indicated | Death |
| Hypocalcemia | <LLN - 8.0 mg/dL; <LLN - 2.0 mmol/L; Ionized calcium <LLN - 1.0 mmol/L | <8.0 - 7.0 mg/dL; <2.0 - 1.75 mmol/L ; Ionized calcium <1.0 - 0.9 mmol/L; symptomatic | <7.0 - 6.0 mg/dL; <1.75 - 1.5 mmol/L; Ionized calcium <0.9 - 0.8 mmol/L; hospitalization indicated | <6.0 mg/dL; <1.5 mmol/L; Ionized calcium <0.8 mmol/L; life-threatening consequences | Death |
| Hypoglycemia | <LLN - 55 mg/dL; <LLN - 3.0 mmol/L | - | - | - | - |
| Hypokalemia | <LLN - 3.0 mmol/L | <LLN - 3.0 mmol/L; symptomatic; intervention indicated | <3.0 - 2.5 mmol/L; hospitalization indicated | <2.5 mmol/L; life-threatening consequences | Death |
| Hypomagnesemia | <LLN - 1.2 mg/dL; <LLN - 0.5 mmol/L | <1.2 - 0.9 mg/dL ;<0.5 - 0.4 mmol/L | <0.9 - 0.7 mg/dL; <0.4 - 0.3 mmol/L | <0.7 mg/dL; <0.3 mmol/L; life-threatening consequences | Death |
| Hyponatremia | <LLN - 130 mmol/L | - | <130 - 120 mmol/L | <120 mmol/L; life-threatening consequences | Death |
| Hypophosphatemia | <LLN - 2.5 mg/dL; <LLN - 0.8 mmol/L | <2.5 - 2.0 mg/dL; <0.8 - 0.6 mmol/L | <2.0 - 1.0 mg/dL; <0.6 - 0.3 mmol/L | <1.0 mg/dL; <0.3 mmol/L; life-threatening consequences | Death |
| Iron overload | - | Moderate symptoms; intervention not indicated | Severe symptoms; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Metabolism and nutrition disorders - Other, specify | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Obesity | - | BMI 25 - 29.9 kg/m2 | BMI 30 - 39.99 kg/m2, or 1 or 2 decimals should be used consistently over both grades | BMI >=40 kg/m2 | - |
| Tumor lysis syndrome | - | - | Present | Life-threatening consequences; urgent intervention indicated | Death |
Articles in category "CTCAE4 Metabolism and nutrition disorders"
There are 24 articles in this category.
