Category:CTCAE4 Psychiatric disorders

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Adverse Event Grade1 Grade2 Grade3 Grade4 Grade5
Agitation Mild mood alteration Moderate mood alteration Severe agitation; hospitalization not indicated Life-threatening consequences; urgent intervention indicated Death
Anorgasmia Inability to achieve orgasm not adversely affecting relationship Inability to achieve orgasm adversely affecting relationship - - -
Anxiety Mild symptoms; intervention not indicated Moderate symptoms; limiting instrumental ADL Severe symptoms; limiting self care ADL; hospitalization not indicated Life-threatening; hospitalization indicated Death
Confusion Mild disorientation Moderate disorientation; limiting instrumental ADL Severe disorientation; limiting self care ADL Life-threatening consequences; urgent intervention indicated Death
Delayed orgasm Delay in achieving orgasm not adversely affecting relationship Delay in achieving orgasm adversely affecting relationship - - -
Delirium Mild acute confusional state Moderate and acute confusional state; limiting instrumental ADL Severe and acute confusional state; limiting self care ADL; hospitalization indicated Life-threatening consequences, threats of harm to self or others; hospitalization indicated Death
Delusions - Moderate delusional symptoms Severe delusional symptoms; hospitalization not indicated Life-threatening consequences, threats of harm to self or others; hospitalization indicated Death
Depression Mild depressive symptoms Moderate depressive symptoms; limiting instrumental ADL Severe depressive symptoms; limiting self care ADL; hospitalization not indicated Life-threatening consequences, threats of harm to self or others; hospitalization indicated Death
Euphoria Mild mood elevation Moderate mood elevation Severe mood elevation (e.g., hypomania) - -
Hallucinations Mild hallucinations (e.g., perceptual distortions) Moderate hallucinations Severe hallucinations; hospitalization not indicated Life-threatening consequences, threats of harm to self or others; hospitalization indicated Death
Insomnia Mild difficulty falling asleep, staying asleep or waking up early Moderate difficulty falling asleep, staying asleep or waking up early Severe difficulty in falling asleep, staying asleep or waking up early - -
Libido decreased Decrease in sexual interest not adversely affecting relationship Decrease in sexual interest adversely affecting relationship - - -
Libido increased Mild increase in sexual interest not adversely affecting relationship Moderate increase in sexual interest adversely affecting relationship Severe increase in sexual interest leading to dangerous behavior - -
Mania Mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep) Moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene) Severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated Life-threatening consequences, threats of harm to self or others; hospitalization indicated Death
Personality change Mild personality change Moderate personality change Severe personality change; hospitalization not indicated Life-threatening consequences, threats of harm to self or others; hospitalization indicated Death
Psychiatric disorders - Other, specify Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL Severe or medically significant but not immediately life-threatening; disabling; limiting self care ADL Life-threatening consequences; hospitalization or urgent intervention indicated Death
Psychosis Mild psychotic symptoms Moderate psychotic symptoms (e.g., disorganized speech; impaired reality testing) Severe psychotic symptoms (e.g., paranoid; extreme disorganization); hospitalization not indicated Life-threatening consequences, threats of harm to self or others; hospitalization indicated Death
Restlessness Mild symptoms; intervention not indicated Moderate symptoms; limiting instrumental ADL Severe symptoms; limiting self care ADL - -
Suicidal ideation Increased thoughts of death but no wish to kill oneself Suicidal ideation with no specific plan or intent Specific plan to commit suicide without serious intent to die which may not require hospitalization Specific plan to commit suicide with serious intent to die which requires hospitalization -
Suicide attempt - - Suicide attempt or gesture without intent to die which may not require hospitalization Suicide attempt with intent to die which requires hospitalization Death
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