Category:CTCAE4 Renal and urinary disorders
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| Adverse Event | Grade1 | Grade2 | Grade3 | Grade4 | Grade5 |
|---|---|---|---|---|---|
| Acute kidney injury | Creatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline | Creatinine 2 - 3x above baseline | Creatinine >3x baseline or >4.0 mg/dL; hospitalization indicated | Life-threatening consequences; dialysis indicated | Death |
| Bladder perforation | - | Extraperitoneal perforation, indwelling catheter indicated | Intraperitoneal perforation; elective radiologic, endoscopic or operative intervention indicated | Life-threatening consequences; organ failure; urgent operative intervention indicated | Death |
| Bladder spasm | Intervention not indicated | Antispasmodics indicated | Hospitalization indicated | - | - |
| Chronic kidney disease | eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) < 60 ml/min/1.73 m2 or proteinuria 2+ present; urine protein/creatinine >0.5 | eGFR or CrCl 59 - 30 ml/min/1.73 m2 | eGFR or CrCl 29 - 15 ml/min/1.73 m2 | eGFR or CrCl < 15 ml/min/1.73 m2; dialysis or renal transplant indicated | Death |
| Cystitis noninfective | Microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence | Moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL | Gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death |
| Hematuria | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL | Gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated; limiting self care ADL | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death |
| Hemoglobinuria | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | - | - | - | - |
| Proteinuria | 1+ proteinuria; urinary protein <1.0 g/24 hrs | Adults: 2+ proteinuria; urinary protein 1.0 | Adults: urinary protein >3.5 g/24 hrs;
Pediatric urine P/C (Protein/Creatinine) >1.9 | - | - |
| Renal and urinary disorders - Other, specify | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate, local or noninvasive intervention indicated; limiting instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Renal calculi | Asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated | Symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated | Hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated | Life-threatening consequences; urgent radiologic, endoscopic or operative intervention indicated | Death |
| Renal colic | Mild pain not interfering with activity; nonprescription medication indicated | Moderate pain; limiting instrumental ADL; prescription medication indicated | Hospitalization indicated; limiting self care ADL | - | - |
| Renal hemorrhage | Mild symptoms; intervention not indicated | Analgesics and hematocrit monitoring indicated | Transfusion, radiation, or hospitalization indicated; elective radiologic, endoscopic or operative intervention indicated | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death |
| Urinary fistula | - | Noninvasive intervention indicated; urinary or suprapubic catheter placement indicated | Limiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated | Life-threatening consequences; urgent radiologic or operative intervention indicated | Death |
| Urinary frequency | Present | Limiting instrumental ADL; medical management indicated | - | - | - |
| Urinary incontinence | Occasional (e.g., with coughing, sneezing, etc.), pads not indicated | Spontaneous; pads indicated; limiting instrumental ADL | Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL | - | - |
| Urinary retention | Urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual | Placement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated | Elective operative or radiologic intervention indicated; substantial loss of affected kidney function or mass | Life-threatening consequences; organ failure; urgent operative intervention indicated | Death |
| Urinary tract obstruction | Asymptomatic; clinical or diagnostic observations only | Symptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated | Symptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic, or operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Urinary tract pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Urinary urgency | Present | Limiting instrumental ADL; medical management indicated | - | - | - |
| Urine discoloration | Present | - | - | - | - |
Articles in category "CTCAE4 Renal and urinary disorders"
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