Category:CTCAE4 Reproductive system and breast disorders
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| Adverse Event | Grade1 | Grade2 | Grade3 | Grade4 | Grade5 |
|---|---|---|---|---|---|
| Azoospermia | - | - | Absence of sperm in ejaculate | - | - |
| Breast atrophy | Minimal asymmetry; minimal atrophy | Moderate asymmetry; moderate atrophy | Asymmetry >1/3 of breast volume; severe atrophy | - | - |
| Breast pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Dysmenorrhea | Mild symptoms; Intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | - |
| Dyspareunia | Mild discomfort or pain associated with vaginal penetration; discomfort relieved with use of vaginal lubricants or estrogen | Moderate discomfort or pain associated with vaginal penetration; discomfort or pain partially relieved with use of vaginal lubricants or estrogen | Severe discomfort or pain associated with vaginal penetration; discomfort or pain unrelieved by vaginal lubricants or estrogen | - | - |
| Ejaculation disorder | Diminished ejaculation | Anejaculation or retrograde ejaculation | - | - | - |
| Erectile dysfunction | Decrease in erectile function (frequency or rigidity of erections) but intervention not indicated (e.g., medication or use of mechanical device, penile pump) | Decrease in erectile function (frequency/rigidity of erections), erectile intervention indicated, (e.g., medication or mechanical devices such as penile pump) | Decrease in erectile function (frequency/rigidity of erections) but erectile intervention not helpful (e.g., medication or mechanical devices such as penile pump); placement of a permanent penile prosthesis indicated (not previously present) | - | - |
| Fallopian tube obstruction | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | - |
| Fallopian tube stenosis | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent operative intervention indicated (e.g., organ resection) | Death |
| Female genital tract fistula | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Feminization acquired | Mild symptoms; Intervention not indicated | Moderate symptoms; medical intervention indicated | - | - | - |
| Genital edema | Mild swelling or obscuration of anatomic architecture on close inspection | Readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour | Lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL | - | - |
| Gynecomastia | Asymptomatic breast enlargement | Symptomatic (e.g., pain or psychosocial impact) | Severe symptoms; elective operative intervention indicated | - | - |
| Hematosalpinx | Minimal bleeding identified on imaging study or laparoscopy; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Irregular menstruation | Intermittent menses with skipped menses for no more than 1 to 3 months | Intermittent menses with skipped menses for more than 4 to 6 months | Persistent amenorrhea for more than 6 months | - | - |
| Lactation disorder | Mild changes in lactation, not significantly affecting production or expression of breast milk | Changes in lactation, significantly affecting breast production or expression of breast milk | - | - | - |
| Menorrhagia | Mild; iron supplements indicated | Moderate symptoms; medical intervention indicated (e.g., hormones) | Severe; transfusion indicated; surgical intervention indicated (e.g., hysterectomy) | Life-threatening consequences; urgent intervention indicated | Death |
| Nipple deformity | Asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex | Symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex | - | - | - |
| Oligospermia | Sperm concentration >48 million/mL or motility >68% | Sperm concentration 13 - 48 million/mL or motility 32 - 68% | Sperm concentration <13 million/mL or motility <32% | - | - |
| Ovarian hemorrhage | Minimal bleeding identified on imaging study or laproscopy; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Ovarian rupture | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Ovulation pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Pelvic floor muscle weakness | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic, not interfering with bladder, bowel, or vaginal function; limiting instrumental ADL | Severe symptoms; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Pelvic pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Penile pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Perineal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Premature menopause | - | - | Present | - | - |
| Prostatic hemorrhage | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Prostatic obstruction | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | - |
| Prostatic pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Reproductive system and breast disorders - Other, specify | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Scrotal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Spermatic cord hemorrhage | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Spermatic cord obstruction | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | - |
| Testicular disorder | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL | Severe symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Testicular hemorrhage | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Testicular pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Uterine fistula | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Uterine hemorrhage | Minimal bleeding identified on imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Uterine obstruction | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | - |
| Uterine pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Vaginal discharge | Mild vaginal discharge (greater than baseline for patient) | Moderate to heavy vaginal discharge; use of perineal pad or tampon indicated | - | - | - |
| Vaginal dryness | Mild vaginal dryness not interfering with sexual function | Moderate vaginal dryness interfering with sexual function or causing frequent discomfort | Severe vaginal dryness resulting in dyspareunia or severe discomfort | - | - |
| Vaginal fistula | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Vaginal hemorrhage | Minimal bleeding identified on clinical exam or imaging study; intervention not indicated | Moderate bleeding; medical intervention indicated | Severe bleeding; transfusion indicated; radiologic or endoscopic intervention indicated | Life-threatening consequences; urgent operative intervention indicated | Death |
| Vaginal inflammation | Mild discomfort or pain, edema, or redness | Moderate discomfort or pain, edema, or redness; limiting instrumental ADL | Severe discomfort or pain, edema, or redness; limiting self care ADL; small areas of mucosal ulceration | Widespread areas of mucosal ulceration; life-threatening consequences; urgent intervention indicated | Death |
| Vaginal obstruction | Diagnostic observations only; intervention not indicated | Mild symptoms; elective intervention indicated | Severe symptoms; elective operative intervention indicated | - | - |
| Vaginal pain | Mild pain | Moderate pain; limiting instrumental ADL | Severe pain; limiting self care ADL | - | - |
| Vaginal perforation | Asymptomatic clinical or diagnostic observations only; intervention not indicated | Symptomatic and intervention not indicated | Severe symptoms; elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Vaginal stricture | Asymptomatic; mild vaginal shortening or narrowing | Vaginal narrowing and/or shortening not interfering with physical examination | Vaginal narrowing and/or shortening interfering with the use of tampons, sexual activity or physical examination | - | Death |
| Vaginismus | Mild discomfort or pain associated with vaginal spasm/ tightening; no impact upon sexual function or physical examination | Moderate discomfort or pain associated with vaginal spasm/tightening; disruption in sexual function and physical examination | Severe discomfort or pain associated with vaginal spasm/ tightening; unable to tolerate vaginal penetration or physical examination | - | - |
Articles in category "CTCAE4 Reproductive system and breast disorders"
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