Category:CTCAE4 Vascular disorders
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| Adverse Event | Grade1 | Grade2 | Grade3 | Grade4 | Grade5 |
|---|---|---|---|---|---|
| Capillary leak syndrome | - | Symptomatic; medical intervention indicated | Severe symptoms; intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Flushing | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Moderate symptoms; medical intervention indicated; limiting instrumental ADL | Symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL | - | - |
| Hematoma | Mild symptoms; intervention not indicated | Minimally invasive evacuation or aspiration indicated | Transfusion, radiologic, endoscopic, or elective operative intervention indicated | Life-threatening consequences; urgent intervention indicated | Death |
| Hot flashes | Mild symptoms; intervention not indicated | Moderate symptoms; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | - |
| Hypertension | Prehypertension (systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg) | Stage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 -99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated. Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated | Stage 2 hypertension (systolic BP >= 160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated
Pediatric: Same as adult | Life-threatening consequences (e.g. malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated
Pediatric: Same as adult | Death |
| Hypotension | Asymptomatic, intervention not indicated | Non-urgent medical intervention indicated | Medical intervention or hospitalization indicated | Life-threatening and urgent intervention indicated | Death |
| Lymph leakage | - | - | - | - | - |
| Lymphedema | Trace thickening or faint discoloration | Marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL | Severe symptoms; limiting self care ADL | - | - |
| Lymphocele | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated | Severe symptoms; radiologic, endoscopic or elective operative intervention indicated | - | - |
| Peripheral ischemia | - | Brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit | Recurring or prolonged (>=24 hrs) and/or invasive intervention indicated | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death |
| Phlebitis | - | Present | - | - | - |
| Superficial thrombophlebitis | - | Present | - | - | - |
| Superior vena cava syndrome | Asymptomatic; incidental finding of SVC thrombosis | Symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy) | Severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting) | Life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery) | Death |
| Thromboembolic event | Venous thrombosis (e.g., superficial thrombosis) | Venous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated | Thrombosis (e.g., uncomplicated pulmonary embolism _venous_, non-embolic cardiac mural _arterial_ thrombus), medical intervention indicated | Life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated | Death |
| Vascular disorders - Other, specify | Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated | Moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL | Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; disabling; limiting self care ADL | Life-threatening consequences; urgent intervention indicated | Death |
| Vasculitis | Asymptomatic, intervention not indicated | Moderate symptoms, medical intervention indicated | Severe symptoms, medical intervention indicated (e.g., steroids) | Life-threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated | Death |
| Visceral arterial ischemia | - | Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit | Prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated | Life-threatening consequences; evidence of end organ damage; urgent operative intervention indicated | Death |
Articles in category "CTCAE4 Vascular disorders"
There are 17 articles in this category.
